Genome-wide variant by serum urate interaction in Parkinson's disease.
Identifieur interne : 000712 ( Main/Exploration ); précédent : 000711; suivant : 000713Genome-wide variant by serum urate interaction in Parkinson's disease.
Auteurs : Arash Nazeri [Canada] ; Tina Roostaei [Canada] ; Shokufeh Sadaghiani [Canada] ; M Mallar Chakravarty [Canada] ; Shirley Eberly [États-Unis] ; Anthony E. Lang [Canada] ; Aristotle N. Voineskos [Canada]Source :
- Annals of neurology [ 1531-8249 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Behavior, Corpus Striatum (diagnostic imaging), Corpus Striatum (metabolism), Disease Progression, Dopamine (deficiency), Dopamine (genetics), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Inositol Polyphosphate 5-Phosphatases, Magnetic Resonance Imaging, Male, Middle Aged, Nortropanes, Parkinson Disease (blood), Parkinson Disease (diagnostic imaging), Parkinson Disease (genetics), Phosphoric Monoester Hydrolases (genetics), Phosphoric Monoester Hydrolases (metabolism), Predictive Value of Tests, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon, Uric Acid (blood).
- MESH :
- chemical , blood : Uric Acid.
- chemical , deficiency : Dopamine.
- blood : Parkinson Disease.
- diagnostic imaging : Corpus Striatum, Parkinson Disease.
- chemical , genetics : Dopamine, Dopamine Plasma Membrane Transport Proteins, Parkinson Disease, Phosphoric Monoester Hydrolases.
- metabolism : Corpus Striatum, Dopamine Plasma Membrane Transport Proteins, Phosphoric Monoester Hydrolases.
- Adult, Aged, Aged, 80 and over, Behavior, Disease Progression, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Inositol Polyphosphate 5-Phosphatases, Magnetic Resonance Imaging, Male, Middle Aged, Nortropanes, Predictive Value of Tests, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon.
Abstract
Serum urate levels have been associated with risk for and progression of Parkinson's disease (PD). Urate-related compounds are therapeutic candidates in neuroprotective efforts to slow PD progression. A urate-elevating agent is currently under investigation as a potential disease-modifying strategy in people with PD. However, PD is a heterogeneous disorder, and genetic variation may explain divergence in disease severity and progression.
DOI: 10.1002/ana.24504
PubMed: 26284320
Affiliations:
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Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Voineskos, Aristotle N" sort="Voineskos, Aristotle N" uniqKey="Voineskos A" first="Aristotle N" last="Voineskos">Aristotle N. Voineskos</name><affiliation wicri:level="1"><nlm:affiliation>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26284320</idno><idno type="pmid">26284320</idno><idno type="doi">10.1002/ana.24504</idno><idno type="wicri:Area/PubMed/Corpus">000373</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000373</idno><idno type="wicri:Area/PubMed/Curation">000373</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000373</idno><idno type="wicri:Area/PubMed/Checkpoint">000373</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000373</idno><idno type="wicri:Area/Ncbi/Merge">001C82</idno><idno type="wicri:Area/Ncbi/Curation">001C82</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C82</idno><idno type="wicri:Area/Main/Merge">000713</idno><idno type="wicri:Area/Main/Curation">000712</idno><idno type="wicri:Area/Main/Exploration">000712</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide variant by serum urate interaction in Parkinson's disease.</title><author><name sortKey="Nazeri, Arash" sort="Nazeri, Arash" uniqKey="Nazeri A" first="Arash" last="Nazeri">Arash Nazeri</name><affiliation wicri:level="1"><nlm:affiliation>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Roostaei, Tina" sort="Roostaei, Tina" uniqKey="Roostaei T" first="Tina" last="Roostaei">Tina Roostaei</name><affiliation wicri:level="1"><nlm:affiliation>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Sadaghiani, Shokufeh" sort="Sadaghiani, Shokufeh" uniqKey="Sadaghiani S" first="Shokufeh" last="Sadaghiani">Shokufeh Sadaghiani</name><affiliation wicri:level="1"><nlm:affiliation>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chakravarty, M Mallar" sort="Chakravarty, M Mallar" uniqKey="Chakravarty M" first="M Mallar" last="Chakravarty">M Mallar Chakravarty</name><affiliation wicri:level="1"><nlm:affiliation>Cerebral Imaging Centre, Douglas Institute, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cerebral Imaging Centre, Douglas Institute, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Clinic and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Voineskos, Aristotle N" sort="Voineskos, Aristotle N" uniqKey="Voineskos A" first="Aristotle N" last="Voineskos">Aristotle N. Voineskos</name><affiliation wicri:level="1"><nlm:affiliation>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="eISSN">1531-8249</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Behavior</term><term>Corpus Striatum (diagnostic imaging)</term><term>Corpus Striatum (metabolism)</term><term>Disease Progression</term><term>Dopamine (deficiency)</term><term>Dopamine (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Follow-Up Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Inositol Polyphosphate 5-Phosphatases</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nortropanes</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (genetics)</term><term>Phosphoric Monoester Hydrolases (genetics)</term><term>Phosphoric Monoester Hydrolases (metabolism)</term><term>Predictive Value of Tests</term><term>Radiopharmaceuticals</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Uric Acid (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Uric Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Parkinson Disease</term><term>Phosphoric Monoester Hydrolases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Phosphoric Monoester Hydrolases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Behavior</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Inositol Polyphosphate 5-Phosphatases</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nortropanes</term><term>Predictive Value of Tests</term><term>Radiopharmaceuticals</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serum urate levels have been associated with risk for and progression of Parkinson's disease (PD). Urate-related compounds are therapeutic candidates in neuroprotective efforts to slow PD progression. A urate-elevating agent is currently under investigation as a potential disease-modifying strategy in people with PD. However, PD is a heterogeneous disorder, and genetic variation may explain divergence in disease severity and progression.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Nazeri, Arash" sort="Nazeri, Arash" uniqKey="Nazeri A" first="Arash" last="Nazeri">Arash Nazeri</name></noRegion><name sortKey="Chakravarty, M Mallar" sort="Chakravarty, M Mallar" uniqKey="Chakravarty M" first="M Mallar" last="Chakravarty">M Mallar Chakravarty</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Roostaei, Tina" sort="Roostaei, Tina" uniqKey="Roostaei T" first="Tina" last="Roostaei">Tina Roostaei</name><name sortKey="Sadaghiani, Shokufeh" sort="Sadaghiani, Shokufeh" uniqKey="Sadaghiani S" first="Shokufeh" last="Sadaghiani">Shokufeh Sadaghiani</name><name sortKey="Voineskos, Aristotle N" sort="Voineskos, Aristotle N" uniqKey="Voineskos A" first="Aristotle N" last="Voineskos">Aristotle N. Voineskos</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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